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Plk1 PBD electrostatic surfaces (blue = positive; red = negative). (A) PLHSpT with bound 1(PDB accession code: 3HIK); (B) PLH*SpT with bound 2a (PDB accession code: 3RQ7) having the portion of the peptide accessing the cryptic pocket shown in yellow and the cryptic pocket overlain yellow mesh and a recently identified “auxiliary pocket” shown with overlain red mesh.
