Table 4.

Summary of genetic lineage and ablation studies in mouse. “+” show cells actively transcribing the gene of interest (e.g. transcribing Pax3). Gray boxes denote progenitors, myoblasts and myofibers entirely derived from the genetically labeled cell population (e.g. Pax3+ cells). Hatched boxes show progenitors, myoblasts, and myofibers where only some of the cells are derived from the genetically labeled cell population. Star denotes timing of tamoxifen delivery in Pax7^CreERT2 mice.

Engleka, K.A., Gitler, A.D., Zhang, M., Zhou, D.D., High, F.A., and Epstein, J.A. (2005). Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Dev Biol 280, 396–406.

Gensch, N., Borchardt, T., Schneider, A., Riethmacher, D., and Braun, T. (2008). Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development 135, 1597–1604.

Haldar, M., Karan, G., Tvrdik, P., and Capecchi, M.R. (2008). Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis. Dev Cell 14, 437–445.

Hutcheson, D.A., Zhao, J., Merrell, A., Haldar, M., and Kardon, G. (2009). Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for beta-catenin. Genes Dev 23, 997–1013.

Kanisicak, O., Mendez, J.J., Yamamoto, S., Yamamoto, M., and Goldhamer, D.J. (2009). Progenitors of skeletal muscle satellite cells express the muscle determination gene, MyoD. Dev Biol 332, 131–141.

Kuang, S., Kuroda, K., Le Grand, F., and Rudnicki, M.A. (2007). Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell 129, 999–1010.

Lepper, C., and Fan, C.M. (2010). Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells. genesis 48, 424–436.

Li, S., Czubryt, M.P., McAnally, J., Bassel-Duby, R., Richardson, J.A., Wiebel, F.F., Nordheim, A., and Olson, E.N. (2005). Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A 102, 1082–1087.

Schienda, J., Engleka, K.A., Jun, S., Hansen, M.S., Epstein, J.A., Tabin, C.J., Kunkel, L.M., and Kardon, G. (2006). Somitic origin of limb muscle satellite and side population cells. Proc Natl Acad Sci U S A 103, 945–950.