Figure 1.

Difference of gut microbial community between hypertensive patients and controls. (A), Difference of alpha diversity between hypertensive (HT) patients and controls. (B), dbRDA based on the Bray-Curtis distances between microbial genera, revealing a hypertensive microbial dysbiosis which overlaps only in part with taxonomic composition in patients and controls. The first two principle components and the ratio of variance contributed is shown. Genera (square) as the main contributors are plotted by their loadings in these two components. Lines connect samples in the same group, and circles cover samples near the center of gravity for each group. (C), Boxplot shows the significantly different genera between patients and controls. Genera with q < 0.05 (Mann-Whitney U-test corrected by FDR) are shown. Only the genera with average relative abundances greater than 0.05% of total abundance in all samples are shown for clarity. Gray and white boxes represent the patients and controls, respectively. For A and C, the boxes represent the interquartile range (IQR) between first and third quartiles and the line inside represents the median. The whiskers denote the lowest and highest values within 1.5 times IQR from the first and third quartiles, respectively. The dots represent outliers beyond the whiskers.