Table 1. Cardiopulmonary values induced by sequential increases in central venous pressure (CVP) in euvolemic, mechanically ventilated, sevoflurane anesthetized dogs.
| Measurements | Target range of CVP | ||||
|---|---|---|---|---|---|
| 3–7 mmHg (baseline) (4.1–9.5 cmH2O) |
8–12 mmHg (10.9–16.3 cmH2O) |
13–17 mmHg (17.7–23.1 cmH2O) |
18–22 mmHg (24.5–29.9 cmH2O) |
23–27 mmHg (31.3–36.7 cmH2O) |
|
| CVP (mmHg) | 5.3 ± 1.5 | 11.9 ± 0.2 | 16.4 ± 0.4 | 21.1 ± 0.5 | 25.3 ± 1.1 |
| Heart rate (beats/min) | 108 ± 15 | 128 ± 18 | 131 ± 13 | 134 ± 12a) | 138 ± 9a) |
| MABP (mmHg) | 88 ± 10 | 85 ± 12 | 87 ± 7 | 88 ± 8 | 90 ± 4 |
| RAP (mmHg) | 4 ± 2 | 11 ± 2 a) | 16 ± 2a) | 19 ± 2a) | 24 ± 2a) |
| PAP (mmHg) | 15 ± 2 | 21 ± 2 a) | 25 ± 1a) | 30 ± 1a) | 35 ± 2a) |
| PCWP (mmHg) | 7 ± 2 | 15 ± 1 a) | 20 ± 2a) | 24 ± 3a) | 30 ± 2a) |
| TPTDCO (l/min) | 1.8 ± 0.3 | 3.0 ± 0.8 | 3.1 ± 0.7 | 3.3 ± 0.7a) | 3.4 ± 0.8a) |
| SVR (dynes/sec/cm5) | 3,686 ± 273 | 2,049 ± 616 | 1,942 ± 502a) | 1,728 ± 417a) | 1,608 ± 361a) |
| SV (ml/beat) | 17 ± 2 | 23 ± 3 | 23 ± 3 | 24 ± 4 | 25 ± 4a) |
| SVV (%) | 14.3 ± 1.4 | 7.6 ± 2.9a) | 7.3 ± 0.8a) | 5.6 ± 1.9a) | 5.7 ± 1.1a) |
| PPV (%) | 10.8 ± 2.9 | 6.0 ± 2.1a) | 3.5 ± 0.9a) | 3.2 ± 0.3a) | 2.9 ± 0.6a) |
| EVLW (ml) | 198 ± 83 | 199 ± 115 | 199 ± 104 | 227 ± 125 | 244 ± 138 |
| PVPI | 2.1 ± 0.2 | 1.9 ± 0.5 | 1.8 ± 0.4 | 1.9 ± 0.6 | 2.1 ± 0.7 |
| PaO2 (mmHg) | 519 ± 68 | 501 ± 50 | 472 ± 113 | 496 ± 47 | 417 ± 92 |
| PaCO2 (mmHg) | 40 ± 3 | 38 ± 2 | 37 ± 2 | 39 ± 3 | 40 ± 3 |
| PIP (cmH2O) | 10 ± 1 | 11 ± 1 | 11 ± 1 | 12 ± 1 | 13 ± 1 |
CVP: central venous pressure, MABP: mean arterial blood pressure, RAP: right atrial pressure, PAP: pulmonary artery pressure, PCWP: pulmonary capillary wedge pressure, TPTDCO: transpulmonary thermodilution cardiac output, SVR: systemic vascular resistance, SV: stroke volume, SVV: stroke volume variation, PPV: pulse pressure variation, EVLW: extravascular lung water, PVPI: pulmonary vascular permeavility index, PaO2: partial pressure of arterial oxygen, PaCO2: partial pressure of arterial carbon dioxide. a) significantlly statistical difference (P<0.05) compared with the baseline value recorded at the CVP of 3–7 mmHg.