Table 3.
Probability (p) values for risk alleles significantly associated with at least one ND measure under the additive model in pooled, European-American, and African-American samples
dbSNP ID | Risk/minor allele | Pooled sample | European-American sample | African-American sample | |||||||||
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MAF | SQ | HSI | FTND | MAF | SQ | HSI | FTND | MAF | SQ | HSI | FTND | ||
rs7030238 | C/C | 0.286 | 0.0030 | 0.0033 | 0.0044 | 0.226 | 0.1047 | 0.0873 | 0.2407 | 0.317 | 0.0145 | 0.0163 | 0.0100 |
rs10512282 | G/G | 0.082 | 0.0256 | 0.0500 | 0.0683 | 0.091 | 0.0456 | 0.0419 | 0.0549 | 0.078 | 0.2055 | 0.349 | 0.3965 |
rs11788456 | G/G | 0.451 | 0.0674 | 0.2436 | 0.1963 | 0.455 | 0.0016 | 0.0102 | 0.0014 | 0.449 | 0.8465 | 0.869 | 0.690 |
rs17189632 | T/A | 0.389 | 0.0003 | 0.0003 | 0.0002 | 0.446 | 0.0042 | 0.0094 | 0.0129 | 0.359 | 0.0103 | 0.0071 | 0.0037 |
rs10121600 | C/a | 0.481 (T) | 0.0005 | 0.0032 | 0.0050 | 0.358 (T) | 0.0039 | 0.0367 | 0.0383 | 0.454 (C) | 0.0218 | 0.0288 | 0.0428 |
rs1924032 | A/G | 0.491 | 0.0435 | 0.1164 | 0.1270 | 0.498 | 0.4877 | 0.8943 | 0.6218 | 0.486 | 0.0477 | 0.0889 | 0.1495 |
rs2067056 | C/a | 0.418 (C) | 0.0911 | 0.3091 | 0.2883 | 0.496 (T) | 0.0236 | 0.1401 | 0.0561 | 0.372 (C) | 0.5822 | 0.7873 | 0.9348 |
The p values that remained significant after correction for multiple testing are shown in bold. The adjusted p values for multiple testing at the 0.05 significance level based on the SNPSpD program are 0.0037, 0.0034, and 0.0045, respectively, for the pooled, EA, and AA samples MAF minor allele frequency; SQ number of cigarettes smoked per day; HSI heaviness of smoking index (0–6 point scale); FTND Fagerström test for ND score (0–10 point scale)
Minor allele differs among samples and is given individually for each sample