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. 2017 Feb 10;9(4):e1379. doi: 10.1002/wsbm.1379

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© 2017 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Simplified mTOR signaling network with interactions inferred from modeling approaches. Depicted is the crosstalk of mTOR with MAPK signaling pathway. Red dashed edges numbered as circled labels represent the interactions and nodes inferred from modeling approaches. Label 1: PI3K dependent regulation of mTORC2 which is independent of negative feedback from S6K to IRS1.43 Label 2: Positive regulation of AMPK by IRS1.44 Label 3: Negative regulation of S6K by mTORC1.45 Label 4: Gab1 was found to be an important adaptor protein between insulin and MAPK signaling that plays a role of a nonlinear amplifier of mitogenic responses.48