Figure 4.

Representation of the steric zipper in DFNKF(I). Top: partial DFNKF(I) crystal packing viewed along the b axis and showing nine sheets. Pairing of the β‐sheets into the steric zippers creates the dry and wet interfaces. The wet interfaces are filled in with water molecules, whereas the closely spaced dry interfaces lack water molecules. Bottom: view along the crystallographic b axis of two facing β‐sheets formed by three parallel β‐strands showing their remarkable shape complementarity, which promotes the formation of the steric zipper. Peptide molecules are shown in black and water molecules are represented by red dots.