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ADC and MMAE PK model schema after an intravenous infusion of brentuximab vedotin. ADC, antibody‐drug conjugate; DAR, drug‐antibody ratio; CL, clearance of ADC by proteolytic degradation; Q2 and Q3, ADC intercompartmental clearance; CLM, MMAE apparent clearance; MMAE, monomethyl auristatin E; Q5, MMAE apparent intercompartmental clearance.
