Table 3.
Parameter Estimates of Final ADC Model
| Parametera | Units | Estimate (%RSE) | BSV %CV (%RSE) |
|---|---|---|---|
| CL | L/d | 1.56 (2.9) | 46.9 (20) |
| V1 | L | 4.29 (1.9) | 13.5 (24) |
| Q2 | L/d | 2.83 (5.9) | 15 fixed |
| V2 | L | 3.83 (6.3) | 25 fixed |
| Q3 | L/d | 0.708 (8.2) | 45.2 (31) |
| V3 | L | 9.52 (8.8) | 106 (19) |
| ΘBW,CL,Q2,Q3 b | — | 0.698 (8.8) | — |
| ΘBW,V1,V2,V3 c | — | 0.503 (8.0) | — |
| ΘSEX,V1 | — | 0.873 (2.5) | — |
| Corr (CL, V1) | — | 0.229 (53) | — |
| σ1 (additive) | μg/mL | 0.0125 fixed | — |
| σ2 (proportional) | %CV | 32.9 (9.8) | — |
σ1 and σ2, variance of the additive and proportional components of the residual error, respectively; ADC, antibody‐drug conjugate; BSV, between‐subject variability; BW, body weight; CL, clearance; %CV, percent coefficient of variation; Q2 and Q3, intercompartmental clearance; %RSE, percent relative standard error of the estimate; V1, central compartment volume; V2 and V3, peripheral compartment volumes.
a
Reference population = 75‐kg male patient.
b
Dependence on BW as CL·(BW/75)0.698, Q2·(BW/75)0.698, Q3·(BW/75)0.698.
c
Dependence on BW as V1·(BW/75)0.503, V2·(BW/75)0.503, V3·(BW/75)0.503.