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Reciprocal signaling between extreme anterior domain (EAD) organizer and cranial neural crest (NC). The EAD secretes signals, including Kinin peptides, that guide the NC into the face. As they migrate into the face, NC cells secrete factors including Wnt/PCP ligands that stimulate EAD convergent extension to form the ‘pre‐mouth array.’ The pre‐mouth array later opens down the midline to form the stomodeum and edges of the future mouth.
