Figure 1.

Diagrammatic representation of PadA protein and N‐terminal F2 domain. (a) PadA precursor comprises 3,646 aa residues with N‐terminal region (1,328 aa), and C‐terminal region (2,318 aa) carrying 14 repeat blocks of 148–152 aa residues and a cell wall anchor motif LPKTG. The F2 region of the PadA polypeptide (657 aa) has been expanded to show the extent of the vWF‐like domain and the approximate positions of NGR, RGT, and AGD motifs. (b) aa sequence of the N‐terminal region 690 aa residues, indicating signal (leader) sequence (in green), the vWF‐like domain (purple), and the three integrin‐recognition motifs, NGR (214–6 aa), RGT (416–8 aa), and AGD (485–7 aa) in red type