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Effects of PP1α depletion on MEK/ERK activation in B-RafV600E and K-RasG12C/D tumor cells. (A to D) Total cell lysates were analyzed by Western blotting. SK-MEL 28 (A), A375 (B), MiaPaCa-2 (C), and PANC-1 (D) cells were infected with two different lentiviral shRNA systems targeting PP1α (shPP1α#1 and shPP1α#2) for 3 days before harvest. pLKO.1 was the control virus. (E) Densitometry of phospho-MEK1/2 signals normalized to total MEK1/2 levels.
