TABLE 5.

Guide RNAs used in this study

Primer	Targeting type	Forward sequence	Reverse sequence
Control	Not applicable	5′-GTCCCCTCCACCCCACAGTG-3′	5′-CACTGTGGGGTGGAGGGGAC-3′
gRNA set 1	Promoter + exon	5′-AGAAGGAGATCACTGCCCTGGCACC-3′	5′-CCTGCTTGCTGATCCACATCTGCTG-3′
gRNA set 2	Promoter + exon	5′-AGAAGGAGATCACTGCCCTGGCACC-3′	5′-TTATTTCGGAGCGAGAGCCG-3′
gRNA set 3	Promoter + exon	5′-CTCCCCGCTCCTCTCCGCGA-3′	5′-TTATTTCGGAGCGAGAGCCG-3′