Table 3.
Comparison of laboratory variables in differentiating active SLE from inactive SLE, using logistic regression analysis
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | p value | Odds ratio | 95% CI | p value | |
| WBC count (/μL) | 0.999 | 0.999–0.999 | 0.009 | |||
| Haemoglobin (g/dL) | 0.408 | 0.298–0.560 | <0.001 | |||
| Platelet count (×1000/μL) | 0.992 | 0.988–0.997 | 0.001 | |||
| Lymphocyte count (/μL) | 0.997 | 0.996–0.998 | <0.001 | |||
| ESR (mm/h) | 1.032 | 1.016–1.048 | <0.001 | |||
| CRP (mg/L) | 1.081 | 1.029–1.137 | 0.002 | |||
| BUN (mg/dL) | 1.049 | 1.002–1.098 | 0.037 | |||
| Cr (mg/dL) | 2.964 | 0.935–9.396 | 0.064 | |||
| Albumin (mg/dL) | 0.022 | 0.005–0.084 | <0.001 | 0.070 | 0.011–0.441 | 0.004 |
| AST (IU/L) | 1.099 | 1.048–1.153 | <0.001 | 1.205 | 1.050–1.383 | 0.007 |
| ALT (IU/L) | 1.023 | 1.000–1.046 | 0.047 | 0.886 | 0.809–0.971 | 0.009 |
| Total bilirubin (mg/dL) | 1.064 | 0.747–1.518 | 0.728 | |||
| Complement 3, mg/dL | 0.951 | 0.934–0.969 | <0.001 | |||
| Complement 4, mg/dL | 0.910 | 0.868–0.955 | <0.001 | |||
| Anti-dsDNA (IU/mL) | 1.009 | 1.005–1.014 | <0.001 | |||
| Urine P/Cr ratio | 5.874 | 1.772–19.470 | 0.003 | |||
| Ex vivo IFN-γ production (IU/mL) | 0.721 | 0.646–0.804 | <0.001 | |||
| Ex vivo IFN-γ production ≤ 7.19 IU/mL | 36.257 | 12.789–102.788 | <0.001 | 49.004 | 5.871–408.991 | <0.001 |
| Concurrent immunosuppressive treatment | 0.054 | 0.017–0.170 | <0.001 | 0.056 | 0.006–0.469 | 0.007 |
AST aspartate aminotransferase, ALT alanine aminotransferase, BUN blood urea nitrogen, Cr creatinine, CRP C-reactive protein, ESR erythrocyte sedimentation rate, IFN-γ interferon gamma, P/Cr protein/creatinine, SLE systemic lupus erythematosus, WBC white blood cell