Table 4.
Main serotypes of S. pneumoniae isolated from patients with invasive pneumococcal disease cared for in Regional Health Care Network 13, according to the isolation period,1998 to 2013
| Serotypes | 1998–2002 n = 222 | Period | Total | p value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2003–2010 n = 479 | Subtotal n = 701 | 2011–2013 n = 95 | n = 796 | ||||||||
| no | %* | no | %* | no | % | no | %* | no | % | ||
| 14 | 45 | 20.3 | 94 | 19.6 | 139 | 19.8 | 6 | 6.3 | 145 | 18.2 | 0.006 |
| 3 | 14 | 6.3 | 42 | 8.8 | 56 | 8.0 | 17 | 17.9 | 73 | 9.2 | 0.004 |
| 19F | 15 | 6.8 | 28 | 5.8 | 43 | 6.1 | 3 | 3.2 | 46 | 5.8 | 0.451 |
| 1 | 12 | 5.4 | 31 | 6.5 | 43 | 6.1 | 0 | 0.0 | 43 | 5.4 | 0.039 |
| 6A | 13 | 5.9 | 20 | 4.2 | 33 | 4.7 | 6 | 6.3 | 39 | 4.9 | 0.501 |
| 6B | 7 | 3.2 | 27 | 5.6 | 34 | 4.9 | 4 | 4.2 | 38 | 4.8 | 0.344 |
| 23F | 8 | 3.6 | 29 | 6.1 | 37 | 5.3 | 0 | 0.0 | 37 | 4.6 | 0.026 |
| 9V | 6 | 2.7 | 25 | 5.2 | 31 | 4.4 | 3 | 3.2 | 34 | 4.3 | 0.262 |
| 18C | 13 | 5.9 | 15 | 3.1 | 28 | 4.0 | 5 | 5.3 | 33 | 4.1 | 0.205 |
| 19A | 13 | 5.9 | 18 | 3.8 | 31 | 4.4 | 2 | 2.1 | 33 | 4.1 | 0.245 |
| 12F | 1 | 0.5 | 18 | 3.8 | 19 | 2.7 | 9 | 9.5 | 28 | 3.5 | <0.001 |
| 4 | 8 | 3.6 | 13 | 2.7 | 21 | 3.0 | 3 | 3.2 | 24 | 3.0 | 0.811 |
| 7F | 7 | 3.2 | 12 | 2.5 | 19 | 2.7 | 2 | 2.1 | 21 | 2.6 | 0.832 |
| 5 | 14 | 6.3 | 1 | 0.2 | 15 | 2.1 | 2 | 2.1 | 17 | 2.1 | <0.001 |
| 11A | 0 | 0.0 | 12 | 2.5 | 12 | 1.7 | 3 | 3.2 | 15 | 1.9 | 0.047 |
| 22F | 3 | 1.4 | 12 | 2.5 | 15 | 2.1 | 0 | 0.0 | 15 | 1.9 | 0.206 |
| 8 | 2 | 0.9 | 5 | 1.0 | 7 | 1.0 | 5 | 5.3 | 12 | 1.5 | 0.006 |
| 9N | 1 | 0.5 | 6 | 1.3 | 7 | 1.0 | 3 | 3.2 | 10 | 1.3 | 0.140 |
%* refers to the total IPD cases in each period
p values in bold are significant