Fig. 5.

Hypoxic exosome-mediated bladder cancer cell proliferation, migration and invasion are dependent on lncRNA-UCA1. a Suppression efficiency of lncRNA-UCA1 shRNA in hypoxic 5637 cells or hypoxic exosomes derived from 5637 cells was detected by qRT-PCR (mean ± S.E.M., *P < 0.05, n = 3). b Cell proliferation assay was performed in UMUC2 cells co-cultured with PBS, hypoxic exosomes derived from 5637 cells transfected with control shRNA or UCA1 shRNA (mean ± S.E.M., *P < 0.05, n = 3). c Migration assay was analyzed on the migratory potential of UMUC2 cells co-cultured with PBS, hypoxic exosomes derived from 5637 cells transfected with control shRNA or UCA1 shRNA (mean ± S.E.M., *P < 0.05, n = 3). d Invasion assay was analyzed on the invasiveness of UMUC2 cells co-cultured with PBS, hypoxic exosomes derived from 5637 cells transfected with control shRNA or UCA1 shRNA (mean ± S.E.M., *P < 0.05, n = 3)