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. 2017 Aug 25;16:143. doi: 10.1186/s12943-017-0714-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Schematic diagram of hypoxic exosomal lncRNA-UCA1-mediated bladder tumor growth and progression. Exosomal lncRNA-UCA1 derived from hypoxic bladder cancer cells promotes more aggressive phenotype of the neighbour cancer cells under normoxia and drives bladder tumor growth and development via EMT and MMP. Moreover, exosomal lncRNA-UCA1 in serum may serve as a potential non-invasive biomarker for bladder cancer diagnosis