Table 3. Genes significantly changed by nicotine at the mRNA level in the six immune-related pathways.
| Gene symbol | Gene | Ratio ± SD | p value | FDRa |
|---|---|---|---|---|
| ARAF1 | V-raf murine sarcoma 3611 viraloncogene homolog 1 | 1.24 ± 0.09 | 0.03 | 0.17 |
| ATF2 | Activating transcription factor 2 | 0.80 ± 0.04 | 0.02 | 0.14 |
| BCL2 | B cell leukemia/lymphoma 2 | 1.24 ± 0.16 | 0.03 | 0.17 |
| FLIP | CASP8 and FADD-like apoptosis regulator | 1.35 ± 0.10 | 0.01 | 0.12 |
| DAXX | Fas death domain-associated protein | 1.25 ± 0.09 | 0.03 | 0.17 |
| DUSP1 | Dual specificity phosphatase 1 | 1.17 ± 0.08 | 0.02 | 0.14 |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E binding protein 1 | 0.65 ± 0.07 | 0.01 | 0.13 |
| FOS | Fos oncogene | 1.28 ± 0.16 | 0.03 | 0.17 |
| FOXO1 | Forkhead box 1 | 0.52 ± 0.10 | 0.00 | 0.05 |
| HMGN1 | High mobility group nucleosomal binding domain 1 | 1.42 ± 0.14 | 0.01 | 0.14 |
| IKKγ | Inhibitor of kappa light polypeptide gene enhancer in B cells, inase gamma | 1.27 ± 0.18 | 0.03 | 0.17 |
| IL6R | Interleukin 6 receptor | 1.17 ± 0.06 | 0.01 | 0.10 |
| IL6ST | Interleukin 6 signal transducer | 0.74 ± 0.06 | 0.01 | 0.12 |
| ITGB1 | Integrin beta 1 | 0.86 ± 0.05 | 0.04 | 0.18 |
| JAK3 | Janus kinase 3 | 0.80 ± 0.10 | 0.02 | 0.16 |
| MAP3K7IP1 | Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 | 1.45 ± 0.17 | 0.01 | 0.11 |
| MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | 0.69 ± 0.07 | 0.00 | 0.04 |
| MAPK14 | Mitogen-activated protein kinase 14 | 1.22 ± 0.19 | 0.05 | 0.18 |
| MEF2D | Myocyte enhancer factor 2d | 1.35 ± 0.08 | 0.04 | 0.18 |
| NGFR | Nerve growth factor receptor | 1.46 ± 0.18 | 0.05 | 0.18 |
| PIK3CG | Phosphoinositide-3-kinase, catalytic, gamma polypeptide | 1.30 ± 0.20 | 0.05 | 0.19 |
| PLA2G4A | Phospholipase A2, group IVA (cytosolic, calcium dependent) | 1.42 ± 0.16 | 0.03 | 0.17 |
| PPM1L | Protein phosphatase 1 (formerly 2C)-like | 1.35 ± 0.24 | 0.03 | 0.17 |
| PPP1CA | Protein phosphatase 1, catalytic subunit, alpha isoform | 1.21 ± 0.08 | 0.02 | 0.15 |
| RAPGEF3 | Rap guanine nucleotide exchange factor (GEF) 3 | 0.84 ± 0.04 | 0.03 | 0.17 |
| RPS6KB1 | Ribosomal protein S6 kinase, 70kD, polypeptide 1 | 1.28 ± 0.13 | 0.04 | 0.17 |
| SFN | Stratifin | 1.14 ± 0.04 | 0.02 | 0.16 |
| TGFB2 | Transforming growth factor, beta 2 | 0.74 ± 0.03 | 0.00 | 0.01 |
| TGFBR2 | Transforming growth factor, beta receptor 2 | 0.57 ± 0.13 | 0.01 | 0.10 |
| TNFRSF10B | Tumor necrosis factor receptor superfamily, member 10b | 1.43 ± 0.15 | 0.04 | 0.18 |
| TRAF6 | Tnf receptor-associated factor 6 | 0.75 ± 0.13 | 0.03 | 0.17 |
| YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 1.21 ± 0.12 | 0.04 | 0.17 |
a
FDR is calculated from the p values of all the genes included in the microarray via the method of Benjamini and Hochberg (1995)