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. Author manuscript; available in PMC: 2017 Nov 10.
Published in final edited form as: Nature. 2016 Oct 12;539(7628):272–275. doi: 10.1038/nature19810

Figure 2.

Figure 2

Photoredox catalyzed C-C bond formation at unactivated sp3 C-H bonds. a, Trifluoroacetamide as the directing group for C-H functionalization. b, Scope of C-C bond formation with respect to the alkene. c, Scope of C-C bond formation with respect to the amine. Solvent is benzotrifluoride unless otherwise indicated. Bn: benzyl; Bu: butyl; dr: diastereomeric ratio; Et: ethyl; Me: methyl; rac: racemic; tBu: tert-butyl; TBS: tert-butyldimethylsilyl; Boc: tert-butyloxycarbonyl; Ph: phenyl; DMF: dimethylformamide; tAmOH: tert-amyl alcohol; dF-CF3ppy: 2-(2,4-difluorophenyl)-5-trifluoromethylpyridine; dtbbpy: 4,4′-di-tert-butyl-2,2′-bipyridine.