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. Author manuscript; available in PMC: 2017 Aug 29.
Published in final edited form as: Behav Brain Res. 2015 Feb 13;284:249–256. doi: 10.1016/j.bbr.2015.01.032

Figure 4.

Figure 4

ARC gene expression after exploration of novel environment. (A) The time course of ARC gene expression was assessed using quantitative PCR. In the VPM, there were no changes in ARC gene expression as a function of novel environment exploration (n=3/time point). (B) In the S1BF, a significant upregulation of ARC gene expression was identified at 15 and 30 minutes after exploring a novel environment in comparison to naïve animals (n=3/time point; naïve: n=6). In addition, ARC gene expression was significantly decreased at 120 minutes after exploration of novel environment in comparison to the peak expression at 15 and 30 minutes (+<0.05). (C) In the hippocampus, a significant increase of ARC gene expression was identified at 15 minutes after exploration of novel environment (n=3/time point) In addition, ARC gene expression was significantly decreased at 120 minutes after exploration of novel environment in comparison to the peak expression at 15 minutes (+<0.05). The data are presented as the mean ± SEM, where, * p<0.05 in comparison to naïve animals.