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Potency of ketoprofen, morphine, and U50,488H in blocking 1% acetic acid (AA)-induced stretching and conditioned place aversion (CPA). ED50 values (±CL) were calculated from the dose-response curve of the respective compounds and expressed as mg/kg.
| Test Drug | AA-induced stretching | AA-induced CPA |
|---|---|---|
| Ketoprofen (mg/kg) | 1.63 (1.23–2.17) | 1.17 (0.69–1.99) |
| Morphine (mg/kg) | 0.45 (0.22–0.49) | 0.13 (0.06–0.29) |
| U50,488H (mg/kg) | 0.25 (0.19–0.32) | inactive |
