Figure 7.
Immunocal protects HT22 cells from toxicity induced by overexpression of Aβ1-42. (a) Representative images of HT22 cells transfected with either empty vector (IRES) or Aβ1-42. Top panels display colored images showing successful transfection of the cells, and bottom panels display decolorized images of cell nuclei to visualize nuclear condensation. Arrows indicate transfected cells. (b) Quantification of apoptosis for 4 independent experiments performed as in (a). Results are shown as mean ± SEM, n = 4. ∗∗∗ indicates p < 0.001 compared to control, and ††† indicates p < 0.001 compared to cells transfected with Aβ1-42 without Immunocal preincubation. Aβ: amyloid-beta; ICAL: Immunocal.