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. 2017 Jul 28;3(2):e000456. doi: 10.1136/rmdopen-2017-000456

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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The role of HMGB1/TLR4 in tendon disease. Schematic diagram illustrating the manner in which early tendinopathy may arise due tenocyte HMGB1 expression/release. An increased stress that a tendon cell experiences results in the release of HMGB1 from tenocytes, which interacts to drive a proinflammatory phenotype with aberrant tendon remodelling towards an early tendinopathic process. HMGB1, high-mobility group protein B1; IL, interleukin.