. 2017 Aug 24;4:2333392817717411. doi: 10.1177/2333392817717411

Table 2.

Profile Panel Markers.

Protein Name	Gene	SNP Marker	Associated Neuropsychiatric Disorders
Catechol-O-methyltransferase	COMT	rs4680	Alcohol abuse^29,30 Methamphetamine abuse³⁰ Heroin dependence^31,32 Cocaine dependence^33,34 Anxiety^35,36 Depression^37,38
Dopamine β-hydroxylase	DBH	rs1611115	Cocaine addiction^39,40 ADHD⁴¹ Methamphetamine abuse⁴² Schizophrenia⁴³
Dopamine D1 receptor	DRD1	rs4532	Depression⁴⁴ Heroin addiction⁴⁵ Alcohol dependence⁴⁵
Ankyrin repeat and kinase domain containing 1/dopamine receptor D2	ANKK1/DRD2	rs1800497	Alcohol and cocaine Dependence⁴⁶ Heroin abuse^32,45,47
Dopamine D4 receptor	DRD4	rs3758653	Anxiety^48,49 Heroin abuse^50-52
Dopamine rransporter SLC6A3	DAT	rs27072	Methamphetamine addiction⁵³
γ-Aminobutyric acid receptor A, γ2 subunit	GABRG2	rs211014	Alcohol abuse⁵⁴ Heroin abuse⁵⁵ Methamphetamine abuse⁵⁵
Opioid receptor, κ1	OPRK1	rs1051660	Mood disorders⁵⁶ Alcohol dependence⁵⁷
Methylenetetrahydrofolate reductase	MTHFR	rs1801133	Bipolar disorder, depression^58,59
Opioid receptor, Mu 1	OPRM1	rs1799971	Heroin addiction⁶⁰ Opioid use disorder⁶¹ Substance use disorder^61,62 Alcoholism^57,63,64
Serotonin receptor 2A	HTR2A	rs7997012	Drug abuse²⁹ Depression⁶⁵
Phenotypic Traits	Risk Factors
Age	16-45 years old^73,66
Personal history	Mental health disorders^29,67-69 Depression^70-72 Alcoholism^73,74 Illicit drug use^75,76 Prescription drug abuse⁷⁷

ADHD, Attention Deficit Hyperactivity Disorder.