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. 2017 Aug 29;13:1744806917727657. doi: 10.1177/1744806917727657

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Schematic of substance P Pseudomonas exotoxin protein–peptide fusion. A truncated variant (PE35) of pseudomonas exotoxin was used for conjugation. PE35 lacks the binding domain of the full-length Pseudomonas exotoxin and was modified to contain only one native cysteine.³⁷ Substance P was conjugated to the PE35 toxin by disulfide bonding; this allows the amidated C-terminal methionine of substance P to be free to interact with the NK1 receptor.