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. 2017 Jun 23;22(8):974–984. doi: 10.1177/2472555217716056

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© 2017 Society for Laboratory Automation and Screening

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — 3D high-content screening platform that uses mIMCD3 cysts grown in hydrogels as an in vitro model for PKD. (A) mIMCD3 shPkd1 cells grown on culture plastic cannot recapitulate cystic structures (left panel); in contrast, mIMCD3 shPkd1 cells can form cysts when grown in a 3D microenvironment (right panel). (B) 3D high-content screening platform that uses mIMCD3 shPkd1 or mIMRFNPKD 5E4 cysts to determine compound efficacy.