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Examples of endogenous antibodies (EA) interference in immunoassays. (A) Sandwich immunoassay. EA can bind both the capture and the detection antibodies. In the case depicted, interference causes a falsely elevated result. (B) Competitive immunoassay. The example shows EA binding both the capture antibody and only the labelled analogue (but not the analyte). In this case, interference will produce a falsely low result.
