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. 2017 Aug 29;12(8):e0183874. doi: 10.1371/journal.pone.0183874

Table 5. Female up-regulated genes in inflammatory and heart development pathways.

Term P-value Adjusted P-value Z-score Combined Score Genes
Regulation of leukocyte activation (GO:0002694) 5.27207E-06 0.004336 -2.5289 13.75908 SPN; LAG3; CD83; VCAM1; CCL21; FOXF1; FES; CCL5; ZC3H12A; TNFAIP3; THY1; TNFRSF4
Regulation of cytokine production (GO:0001817) 4.10711E-05 0.011260 -2.4979 11.20706 SPN; NFKBIA; AFAP1L2; LAG3; CD83; ZC3H12A; CASP1; TNFAIP3; TNFRSF4; CX3CL1; MB21D1; MAPK13
Taxis (GO:0042330) 3.90027E-05 0.011260 -2.3959 10.74952 SPN; VCAM1; CCL21; CCL5; CCL4; CXCL1; SLIT3; TREM1; CX3CL1
Chemotaxis (GO:0006935) 3.90027E-05 0.011260 -2.3933 10.73764 SPN; VCAM1; CCL21; CCL5; CCL4; CXCL1; SLIT3; TREM1; CX3CL1
Cell chemotaxis (GO:0060326) 5.62173E-05 0.013211 -2.2419 9.699928 VCAM1; CCL21; CCL5; CCL4; CXCL1; TREM1; CX3CL1
Negative regulation of immune system process (GO:0002683) 0.00013572 0.020580 -2.4380 9.467821 SPN; NFKBIA; LAG3; CCL21; FOXF1; ZC3H12A; TNFAIP3; THY1; NBL1
Regulation of inflammatory response (GO:0050727) 0.000155026 0.021251 -2.4038 9.257948 SPN; FOXF1; CCL5; CASP1; TNFAIP3; CX3CL1; CFB; MAPK13
Inflammatory response (GO:0006954) 0.000111624 0.020402 -2.3622 9.193863 AOC3; AFAP1L2; VCAM1; CCL21; CCL5; CCL4; TNFAIP3; CXCL1; TNFRSF4; PTGES
Regulation of immune effector process (GO:0002697) 0.000240717 0.030460 -2.4394 8.51707 SPN; LAG3; FOXF1; FES; TNFAIP3; TNFRSF4; CFB; MB21D1
Regulation of lymphocyte activation (GO:0051249) 0.000282146 0.032930 -2.4716 8.436548 SPN; LAG3; CD83; VCAM1; CCL21; CCL5; TNFAIP3; THY1; TNFRSF4