Table 1.

Summary of effective dose of metformin in studies

Antitumor effect of metformin	500 mg/day15 The greater the metformin exposure, the stronger the risk reduction18
Antiaging effect of metformin	0.1% metformin in diet54
Cardiovascular protective effects of metformin	Starting with one 850 mg tablet per day, then 850 mg twice a day, and then 1,700 mg in the morning and 850 mg with the evening meal (maximum dose =2,550 mg)56 1.4±0.2 g10
Neuroprotective effect of metformin	Starting with 0.5 g tablet, two tablets a day with meals. If the blood glucose level is not controlled for 7 days after taking metformin, it should be increased to 1.5 g/day over 2 weeks (maximum dose <2.0 g/day)85 1,000 mg twice a day86
Polycystic ovary syndrome	Range from 850 to 1,700 mg