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Ishikawa diagram illustrating the parameters influencing the quality of the nanonized LAM containing NP product.
Abbreviations: LAM, lamotrigine; NP, nasal powder; API, active pharmaceutical ingredient; PVP_K25, polyvinylpyrrolidone K25; NaHA, sodium hyaluronate; SEM, scanning electron microscopy; DSC, differential scanning calorimetry; XRPD, X-ray powder diffraction; GI, gastrointestinal; CNS, central nervous system.
