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. 2017 Apr 19;20(8):634–643. doi: 10.1093/ijnp/pyx026

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© The Author 2017. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Short-latency intracortical inhibition and intracortical facilitation before and after drug administration. Single-pulse standardized double stimulation MEP amplitude ratios ± SEM are depicted for ISIs revealing inhibitory (ISIs of 2, 3, and 5 ms) and facilitatory (ISIs of 10 and 15 ms) effects for different medication conditions: single-dose placebo (sPLC), single-dose RBX (sRBX), chronic reboxetine+placebo medication at the day of experiment (cPLC), and chronic reboxetine+reboxetine at the day of experiment (cRBX). (A) The sRBX post condition significantly increased facilitation for the ISI of 15 milliseconds and decreased inhibition for ISIs of 2, 3, and 5 milliseconds compared with sPLC post condition. (B) cRBX post showed a significant increase of facilitation for the ISIs of 10 and 15 milliseconds and a significant decrease of inhibition for the ISI of 3 and 5 milliseconds compared with cPLC post. (C) cRBX post showed significant facilitation for the ISIs of 10 and 15 milliseconds and significant decrease of inhibition for the ISIs of 2 and 5 milliseconds compared with sRBX post. (D) cPLC post showed a nonsignificant trend towards enhanced facilitation and decreased inhibition compared with sPLC post. Asterisks indicate significant differences (Student’s t test, P<.05). Vertical bars depict SEM.