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. 2017 Apr 19;20(8):634–643. doi: 10.1093/ijnp/pyx026

Figure 4.

Figure 4.

I-wave facilitation before and after drug administration. Single-pulse standardized double stimulation MEP amplitude ratios ± SEM are depicted for ISIs of 1.1, 1.3, 1.5, 2.3, 2.5, 2.7, 2.9, 4.1, 4.3, and 4.5 milliseconds with different conditions: single-does placebo (sPLC), single-dose reboxetine (sRBX), chronic reboxetine+placebo medication at the day of experiment (cPLC), and chronic reboxetine+reboxetine at the day of experiment (cRBX). (A) sRBX post significantly enhanced MEP amplitude at all ISIs compared with sPLC post. (B) cRBX post significantly enhanced I-wave facilitation at most ISIs compared with cPLC post. (C) cRBX post revealed a significant enhancement of facilitation at most ISIs compared with sRBX post. (D) cPLC post demonstrated significantly increased facilitation at all ISIs compared with sPLC post. Asterisks indicate significant differences (Student’s t test, P<.05). Vertical bars depict SEM.