Table 1.

Protein‐coding thermal adaptation loci in Anolis cybotes populations

RAD ID	SNP pos (Genomic location)	z‐Score	P	Human gene symbol	Human gene function Clinical relevance	Loc	E value annotation	ID %
54986	62 (GL344061.1:58534‐58623)	−5.26	1.9E‐7	GLTSCR2	Mitochondrial oxygen consumption1 Glioma suppressor	I	6.7E‐44	100
58260	35 (AAWZ02041818:5129‐5204)	−5.43	7.47E‐8	SIRT6	Histone modification Tumor suppressor Aging, Hypoxia	E	7.4E‐35	97
69162	39, 66 (4:134669884‐134669973)	−5.14 −4.96	3.58E‐7	PHF20	Histone modification Medulloblastoma	trI	5.1E‐39	96
87564	63; 78 (2:119357203‐119357268)	−5.12 −5.26	4.09E‐7	ASF1B	Histone Chaperone	trI	1E‐10	88
91548	89 (GL343952.1:63056‐63145)	−5.91	4E‐6	DYNC1H1*	Cell Movement CNS movement Axon Myelination2 Brain malformation	E	8.9E‐40	94
9501	34, 42, 70 (5: 132959521‐132959610)	−5.01 −4.95 −4.97	6E‐6	LRBA	Immune system Immune deficiency w. Autoimmunity; IBS	I	4.4E‐40	94
52394	19, 29 (2:134658466‐134658555)	−5.60 −5.12	4E‐7	MFSD6	Solute Carrier	I/E	1.8E‐35	89
10221	89 (GL343426.1:503906‐503995)	−5.91	1E‐7	MROH7/ HEATR8*	Unknown	E	2.1E‐36	90
85436	43 (GL343638.1:258914‐25900)	−5.49	5.8E‐7	RAP1GAP2	Endothelial damage repair Asthma 3	I	8.2E‐29	84
76510	9, 27, 40 (1:231382954‐231383015)	−4.91 −5.73 −5.41	8E‐7	RASGRP3	RAS activation Upregulated in cancer	I	4.2E‐24	94
72187	17 (GL343258.1:709115‐709204)	−5.06	3E‐6	SOX9	Skeletal development Campomelic dysplasia	I/E	3.2E‐41	96
13877	30 (GL343709.1:169329‐169348)	−5.41	8E‐7	UBE4B	Protein ubiquitination Neuroblastoma suppressor	I	3.8E‐03	100
27048	71 (1:263596451‐263596540)	−5.42	7E‐7	SPTBN1	Cell adhesion Bone mineral density4 Cardiac Arrhythmia, Bone fracture risk	E	2.0E‐43	99
65181	65, 77, 83 (6:21689596‐21689685)	−6.18 −5.42 −4.79	8E‐6	CALCR	Calcium excretion Ossification Osteoporosis	E	2.6E‐42	98

SNPs assigned to protein‐coding outlier loci. ID % refers to sequence similarity with A. carolinensis reference genome. Significance level adjusted with false‐positive discovery rate at p < .007. P = p‐value of outlier. Loc = SNP location: I—Intron, E—Exon, trI—transcribed Intron (RNA reads were observed via ENSEMBL.org). Clinical relevance was obtained from OMIM and PubMed, both for animal model and human. Table references (superscript numbers): (1) Yoon et al., 2014; (2) Yang et al., 2015; (3) Myers et al., 2014; (4) Estrada et al., 2012. *Not in Interactome.