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. 2017 Aug 29;7:9793. doi: 10.1038/s41598-017-09470-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serelaxin improved renal function of DOCA-salt rats. (a) DOCA induced a decrease in glomerular filtration rate and treatment with serelaxin reversed the decrease in glomerular filtration rate. (b) DOCA markedly increased urine albumin/creatinine excretion rate, and treatment with serelaxin significantly decreased urine albumin/creatinine excretion rate. (c) DOCA induced a marked increase in urinary KIM1 excretion and treatment with serelaxin significantly decreased and normalized KIM1 excretion. (d) DOCA increased glomerular extracellular matrix accumulation and mesangial expansion, as determined by Periodic acid–Schiff (PAS) staining, and treatment with serelaxin markedly decreased the matrix accumulation and mesangial expansion. Results are expressed as means ± SEM (n = 6 rats). Statistical analysis was performed with one-way ANOVA.