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. 2017 Aug 29;7:9793. doi: 10.1038/s41598-017-09470-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serelaxin decreased kidney inflammation. Quantitative real-time PCR (qRT-PCR) analysis showed that treatment with serelaxin prevented the increases in the inflammatory markers (a) IL-1-β, (b) IL-6, (c) ICAM-1, (d) VCAM-1, (e) MCP-1, and (f) NFκB mRNA. Serelaxin also prevented the increases in (g) CD68 immunostaining and (h) phospho-NFκB protein abundance in the kidney. Equal protein loading was verified by using an anti-β-actin antibody. The detection was executed by an ECL western blotting analysis system. Whole bolts are reported in Supplemental Fig. 1. Results are expressed as means ± SEM (n = 6 rats for qRT-PCR, n = 3 for western blot). Statistical analysis was performed with one-way ANOVA.