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. 2017 Aug 29;7:9793. doi: 10.1038/s41598-017-09470-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serelaxin decreased kidney lipid accumulation. (a) Representative images of oil red O staining (20 X), which staining for neutral lipids, showed that increased neutral lipid accumulation in kidney of DOCA-salt rats was prevented by the treatment with serelaxin. The expression of fatty acid, triglyceride and cholesterol metabolism related genes were determined by quantitative real-time PCR (qRT-PCR) analysis, (b) SREBP-1c, (c) ChREBP, (d) FATP1, (e) Acox1, (f) SREBP-2, (g) HMGCR, (h) LDLR, (i) ABCA1. (j) Serelaxin regulated the genes involved in fatty acid, triglyceride, and cholesterol metabolism in DOCA-salt rats. Results are expressed as means ± SEM. Statistical analysis was performed with one-way ANOVA.