Figure 2.

The most significantly relevant pathways and highly linked molecules (identified molecules from 17 preclinical studies which to explore the potential mechanisms of TLs for pancreatic cancer) relevant to the merged bionetwork. In the network, molecules are represented as nodes, and the biological relationship between two nodes is represented as a line. Red nodes and green nodes represent up- and down-regulated molecules, respectively. Yellow symbols represent three signaling pathways related to the merged bionetwork. One pathway on the right side of the bionetwork “Pancreatic Adenocarcinoma Signaling” indicates the highly linked molecules and pancreatic cancer signaling pathways. Solid lines between molecules show a direct physical relationship between molecules, whereas dash lines show indirect functional relationships.