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. 2017 Aug 29;7:9686. doi: 10.1038/s41598-017-09671-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-6, TNFα and RANKL expression decreased in gastric mucosa of patient2 and patient3 after them receiving celecoxib treatment. P2, patient2; P3, patient3. (a,d,g and j) showed immunohistochemical staining of IL-6. (b,e,h and k) showed immunohistochemical staining of TNFα. (c,f,i and l) showed immunohhistochemical staining of RANKL. Patient2 and patient3 received celecoxib treatment for three months. IL-6, TNFα and RANKL expression in their gastric mucosa decreased after the treatment (d–f, j–l). Immunostained specimens were assessed by pathologists blinding to clinical features.