Figure 4.
Effect of riluzole on anti-tumour activity of oxaliplatin in in vitro and in vivo assays. (a) C-26 cells were exposed to oxaliplatin (50 µM) for 24 h in the presence or absence of various concentrations (1, 3 or 10 µM) of riluzole. (b) C-26 cells-implanted mice were treated with oxaliplatin (6 mg/kg, i.p.) twice a week (days 1, 2, 8 and 9) and riluzole (18 mg/kg, p.o.) once a day for 2 weeks. The tumour volumes were calculated as follows: Volume (mm3) = π/6 × Thickness (mm) × Length (mm) × Width (mm). Values are expressed as the mean ± SEM ((a) n = 4, ***P < 0.001 vs. control, (b) n = 10–11, ***P < 0.001 vs. vehicle).