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. 2017 Aug 29;7:9882. doi: 10.1038/s41598-017-10003-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Measuring model fitting. Plots show the agreement metrics between simulated and empirical data for the Healthy (H-AM, gray & H-NAM light blue), ON (green) and OFF (orange) groups. The three panels represent the measurements of fitting, metastability and ks-distance (see Methods) as a function of the coupling strength parameter G. The gray area represents the 20 continuous couplings from which the bifurcation parameter values were selected to construct their corresponding distributions.