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. 2017 Aug 29;7:9763. doi: 10.1038/s41598-017-10068-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological and molecular criteria of BPH and CaP samples used in Microarray analysis. (a) H&E stained tissue sections of BPH and CaP samples. (b) Semi-quantitative RT-PCR based evaluation of AR and KLK3 genes in patient samples. Glucose-6-phosphate dehydrogenase (GAPDH) was used as an endogenous control. (c) Bar diagram representing relative expression of cell cycle and proliferation genes by quantitative RT-PCR. (***) indicated the P value < 0.001. 18 S rRNA gene was used as an endogenous control. (d) Representative western blots of cyclinD1, CDK4, p21 and c-Myc and in cancer and BPH samples. Human β-actin was used as loading control. Bar diagram in the lower panel showed the fold decrease of proteins in cancer tissues compared to BPH samples. (*) indicated the P value < 0.05. (e) Immunohistochemical evaluation of expression of cyclinD1, CDK4 and Ki-67 proteins in BPH and cancer samples (Bar: 50 µm).