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. 2017 Aug 29;7:9763. doi: 10.1038/s41598-017-10068-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relative expression and functional categorization of differentially regulated genes belonging to the AR receptor signaling pathway. (a) Bar diagram showing average fold difference of 94 genes in CaP with respect to BPH. The height of each bar represents Log₁₀RQ of the genes. White colored bars represent over expressed genes belonging to the androgen/intracellular steroid receptor pathway. Box plot in the inset represents an overall higher expression of AR pathway genes in cancer. The bottom line, middle line, and top line of each box represent 25th percentile, median, and 75th percentile, respectively. Bars extend to the lowest value and to the highest value of ΔCq of each group. (b) Differentially regulated genes were categorized based on their affiliations to different Biological Processes or Molecular Functions. Each category was represented by two bars for genes up regulated and down regulated. The height of the bar indicates the number of input genes observed within the category.