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. 2017 Aug 29;7:9763. doi: 10.1038/s41598-017-10068-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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c-Myc binds to and regulates the FKBP4 promoter. (a) Map of the putative c-Myc binding sites on the FKBP4 promoter, 1 KB upstream of the translation start site. (b) Multiple sequence alignment of FKBP4 promoter sequences of taxonomically different organisms showing the most conserved site. (c) Bar diagrams representing the relative luciferase expression in FKBP4 construct with respect to empty pGL3 basic vector, in the presence or absence of c-Myc siRNA. (d) c-Myc antibody mediated chromatin immunoprecipitation coupled with PCR of genomic region flanking the most conserved E-box in the FKBP4 promoter, as represented by semi-quantitative RT-PCR. IgG was used as a negative control. (e) qPCR of FKBP4 promoter using INPUT and c-Myc specific ChIP samples.