Table 1.
Enriched GO categories and genes overexpressed in prostate cancer (>1.5 fold).
| Sub-root | Category name and corresponding GO ID | Detectors (Genes) | rawP | adjP |
|---|---|---|---|---|
| Biological process | positive regulation of metabolic process ID:GO:0009893 ID:GO:0031325 | SOAT1,RCHY1, POR, FOXO3, SRY, CALR, HPRT1, NCOA4, IL6, PIAS2,MED24, AR, MED17,SCRAB1, MED14, SPDEF, FGF8, MED1,NCOA2 | 4.49e-08 1.31e-07 | 5.47e-06 1.20e-05 |
| Biological process | positive regulation of biosynthetic process ID:GO:0009891 ID:GO:0031328 | SOAT1, POR, FOXO3, SRY, CALR, NCOA4, IL6, PIAS2, MED24, AR, MED17, SPDEF, MED14, SCRAB1,MED1,NCOA2 | 2.33e-08 1.80e-08 | 3.41e-06 3.29e-06 |
| Biological process | intracellular steroid hormone receptor signaling pathway ID:GO:0030518 ID:GO:0030522 ID:GO:0030521 | CALR, NCOA4, PEMPA1, PIAS2, AR, MED24, MED17, MED1, FKBP4, PARK7, NCOA2 | 1.23e-17 1.40e-14 2.95e-18 | 4.50e-15 3.41e-12 2.95e-18 |
| Biological process | sex differentiation ID:GO:0007548 | NCOA4, AR, MED1, FKBP4, FGF8, FOXO3, SRD5A1, SRY | 2.21e-07 | 1.62e-05 |
| Molecular function | transcription factor binding transcription factor activity ID:GO:0000989 ID:GO:0003713 | MED24, MED17, TGIF1, MED14, NCOA4, MED1, NCOA2, PIAS2 | 1.93e-05 3.83e-06 | P = 0.0002 4.47e-05 |
| Molecular function | steroid hormone/ androgen receptor binding ID:GO:0005102 ID:GO:0051427 ID:GO:0035257 | CALR, NCOA4, IL6, PIAS2, AR, RCHY1, MED24, MED17, MED14, MED1, FKBP4, FGF8, NCOA2 | 3.77e-06 2.79e-12 7.90e-13 | 4.47e-05 1.46e-10 8.29e- 11 |
| Molecular function | vitamin D receptor & thyroid hormone binding ID:GO:0042809 ID:GO:0046966 | MED24, MED17, MED14, MED1 | 7.55e-08 8.50e-07 | 1.59e-06 1.49e-05 |
*Similar biological processes and molecular functions were clubbed and presented in the same row
**The genes marked in bold were subjected to further molecular analyses.