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. 2017 Aug 29;7:9848. doi: 10.1038/s41598-017-10329-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in the expression of TLR mRNAs in HCV-infected tupaias at 41 wpi. (A) TLR3, (B) TLR7, and (C) TLR8 mRNA expression in livers of HCV-infected tupaias was measured by one-step qRT-PCR. Gene expression levels were normalized to the expression level of GAPDH mRNA. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 indicate significant differences compared to normal controls. Data are presented as means ± SDs (n = 3).