Fig. 5.

Cell-specific targeting, siRNA transfection, and Dox delivery using QDHs. a Cell-specific targeting with aptamer in CCL-119 cells. Uptake of QDH and QDH-A were measured using flow cytometry. One-way ANOVA, *P < 0.05. b Determination of siRNA delivery with QDH. EGFR was knocked down in HeLa cells with: lane 1: Untreated; 2: EGFR siRNA; 3: EGFR siRNA-aptamer; 4: silencer; 5: QDH-EGFR siRNA. c Cellular localization of Dox, ZnS-QDH, and Dox-ZnS-QDH. d Comparison of LC₅₀ values of Dox and Dox-ZnS-QDH at 3, 24, and 72 h. All error bars represent s.e.m. (n = 4). See Supplementary Fig. 8 for full blot