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. 2017 Aug 29;7:9580. doi: 10.1038/s41598-017-10057-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduction of Dm eIF5A function affects Dia formin levels. (A,B) Confocal images of a representative stage 13 en-GAL4>UAS-GFP; UAS-iReIF5A (en>GFP>iReIF5A) embryo stained with anti-Dia. A lateral view of the epidermis is shown. Anterior it to the left, dorsal is up. (A) Overlay of the en-GAL4 positive bands, identified by GFP expression, and Dia localization. (B) Image of the anti-Dia staining in which yellow lines represent the limits of the en-GAL4 positive bands. Decreased Dia levels are observed in cells with reduced eIF5A function (GFP marked cells) when compared to nearby non-GFP wild-type cells. Scale bar: 25 µm. (C) Quantification of the anti-Dia signal intensity (fluorescence intensity) in eIF5A mutant cells (GFP) with respect to control cells (Non-GFP). Data are represented as mean ± SD. Two-tailed student’s t-test analysis: *p < 0.05.