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. 2017 Aug 29;7:9591. doi: 10.1038/s41598-017-10391-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Correlation network between the differential metabolites and DG or VLX. Red-coloured boxes indicate upregulation in the DG or VLX group compared with DEP, while green-coloured boxes indicate downregulation in the DG or VLX group, compared with DEP. The line colours represent the fold changes of differential metabolites. The line width represents the VIP scores of the differential metabolites. (B) Heat map the differential metabolites in the comparison of the DG and DEP groups. (C) Heat map of differential metabolites in the comparison of the VLX and DEP groups. DG, diterpene ginkgolides; VLX, venlafaxine.