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. 2017 Aug 29;7:9808. doi: 10.1038/s41598-017-09622-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High spatial resolution ¹⁹F MR image of an ex vivo brain from an EAE mouse showing clinical disease. With both ¹⁹ F-CRP and ¹⁹ F/¹ H RT-coil, ¹⁹F MR images were acquired using a 3D-RARE sequence. ¹⁹F MR images (shown in red) were combined with ¹H MR images (shown in grayscale). ¹H MR images were acquired using a 3D-FLASH sequence and the ¹⁹ F/¹ H RT-coil. (A) Three exemplary slices from horizontal views of combined ¹⁹F/¹H MR images for both ¹⁹ F/¹ H RT-coil (upper panel) and ¹⁹ F-CRP (middle panel), in the lower panel a 300% zoom of the ¹⁹F/¹H MR images acquired with the CRP. (B) Three exemplary slices from coronal views of combined ¹⁹F/¹H MR images for both RT coil (upper panel) and CRP (middle panel). Registration of the Allen brain atlas to the ¹H image (lower panel) shows following labelled brain regions: rs: retrosplenial area; crn: cranial nerves; sc: superior colliculus (sensory related); pmv: posteromedial visual area; ps: postsubiculum; av: arbor vitae; cbn: cerebellar nuclei. (C) 3-D rendering of the combined ¹⁹F/¹H MR images for both ¹⁹ F/¹ H RT-coil (upper panel) and ¹⁹ F-CRP (lower panel).