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. 2017 Aug 29;7:9617. doi: 10.1038/s41598-017-09183-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The p values from a t-test between results from the Poisson and the Poisson Plus modeling, at each concentration, is given as follows: 0.00000117, 0.04, 0.000003, 0.0002, 0.000004. The results suggest a significant difference in the means of the two distributions at the 95% confidence level at these concentrations. The mean result from each model along with a ± one standard deviation around this mean value is shown in the figure. The Poisson Plus results are consistently closer to the line of equivalence constructed with the expected results, suggesting a greater accuracy of the Poisson Plus Model at these concentrations.